Journal
PLATELETS
Volume 21, Issue 4, Pages 297-299Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/09537101003612813
Keywords
Lead poisoning; thrombocytosis; DMSA; severe itching; chelation therapy
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We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal<5). Chelation therapy with DMSA resulted in complete recovery of the hyperpigmentation, itching and thrombocytosis. Lead poisoning should be considered in the differential diagnosis of obscured thrombocytosis.
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