Journal
PLATELETS
Volume 21, Issue 3, Pages 167-175Publisher
INFORMA HEALTHCARE
DOI: 10.3109/09537101003611385
Keywords
Membrane structures; OCS; small GTPase; aggregation; cytoskeleton
Categories
Funding
- National Institutes of Health (NIH) [HL56652, HL091893]
- AHA Great Rivers Affiliate [0615112B]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL056652, R01HL091893] Funding Source: NIH RePORTER
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Platelets contain an invaginated, tubular membranous structure called the surface-connected open canalicular system (SCCS or OCS), which is contiguous with the plasma membrane and serves as a site for granule fusion and as a reservoir of membrane for platelet spreading. According to ultrastructural studies, platelets from some species lack OCS. In an attempt to correlate biochemical and functional attributes with the presence of an OCS, platelets from human, mouse and dog (OCS
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