Journal
PLASMID
Volume 64, Issue 3, Pages 119-134Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.plasmid.2010.06.004
Keywords
RK2 plasmid; Replication initiation; Partitioning; Global regulatory network
Categories
Funding
- Polish Ministry of Science and Higher Education [N N301 295837]
- Foundation for Polish Science
- European Social Fund
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The broad-host-range plasmid RK2 has been a model for studying DNA metabolism in bacteria for many years. It is used as a vector allowing genetic manipulations in numerous bacterial species. The RK2 genome encodes several genes providing the plasmid with diverse functions allowing for its stable maintenance in a variety of bacterial hosts. This review will focus on two processes indispensable for plasmid DNA maintenance. We will summarize recent understanding of the molecular mechanisms contributing to the RK2 DNA replication and partitioning. (C) 2010 Elsevier Inc. All rights reserved.
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