Journal
PLASMA PROCESSES AND POLYMERS
Volume 11, Issue 11, Pages 1076-1088Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201400072
Keywords
angiogenesis; burn wound; nitrides; non-thermal plasma; reactive nitrogen species (RNS); reactive oxygen species (ROS); re-epithelialization
Funding
- National Science Council of Taiwan [NSC 101-2321-B-006-012]
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Non-thermal 0.5% N-2/Ar micro-plasma treatment with relatively high NO content was conducted on mice with second-degree burn wounds. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) concentrations in the plasma-exposed tissue lysate were measured. The wound closure kinetics, inflammatory responses, proliferation phase, blood flow, and formation of blood vessels in the mice were then assessed. The results showed that the wound contraction in the plasma-exposed mice occurred five days earlier than that in the control group. The generated ROS/RNS signals stimulated the burn wound healing process, which were correlated with the angiogenesis and epithelialization processes. A possible in vivo mechanism for the enhancement of the processes in the plasma-exposed mice is thereafter proposed.
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