Journal
PLASMA PROCESSES AND POLYMERS
Volume 11, Issue 12, Pages 1142-1149Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.201400111
Keywords
apoptosis; cancer; nitric oxide; plasma jet; radicals
Funding
- EPSRC Science and Innovation grant
- UK EPSRC [EP/H003797/1]
- Northern Ireland Department of Employment and Learning PhD studentship
- Engineering and Physical Sciences Research Council [EP/H003797/2, EP/H003797/1] Funding Source: researchfish
- EPSRC [EP/H003797/2, EP/H003797/1] Funding Source: UKRI
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The effect of a radio-frequency driven, microscale non thermal atmospheric pressure plasma jet operated in helium with vol. 0.3% molecular oxygen gas admixture, on PC-3 prostate cancer cells has been investigated. The viability of cells exposed to the plasma was found to decrease with increasing plasma exposure time, with apoptosis through caspase and PARP cleavage being observed. High concentrations of nitrite and nitrate were detected in growth media exposed to the plasma and were found to increase in a time dependent manner post exposure. This indicates a slow release of reactive nitrogen species into the growth media, which is likely to influence cellular response to plasma exposure.
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