Journal
PLANTA MEDICA
Volume 79, Issue 15, Pages 1453-1460Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1350769
Keywords
Illicium henryi; Illiciaceae; root; sesquiterpene; illihenlactoneoside A; neurotoxicant activity
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Funding
- Natural Science Foundation of China [201072234, 21132009]
- National Science and Technology Project of China [2012ZX09301002-002, 2011ZX0 9307-002-01]
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Seven new sesquiterpenoid glycosides, consisting of one thapsan-type (1), two capnellane-type (2 and 3), four floridanolide sesquiterpene glycosides (4-7), and one new azulene-type sesquiterpene (8), along with six known sesquiterpenes (9-14) were isolated from the roots of Illicium henryi. The structures of 1-8 were elucidated by extensive spectroscopic analyses and chemical methods. The absolute configurations of 1, 2, and 8 were determined based on Rh-2(OCOCF3)(4)-induced CD, Mo-2(OAc)(4)-induced CD data, and calculated electronic circular dichroism (ECD), respectively. Compound 1 was found to exhibit weak neurotoxicant activity.
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