Journal
PLANTA MEDICA
Volume 79, Issue 9, Pages 731-736Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1328551
Keywords
icariin; lipid-lowering effect; prothrombotic state; atherosclerosis; Epimedium brevicornum; Berberidaceae
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Funding
- Department of Science & Technology of Shaanxi Province in China [2009K18-01]
- National Natural Science Foundation of China [81102843]
- National Science Fund for Distinguished Young Scholars [81025002]
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Icariin is a major active component isolated from the traditional Chinese herb Epimedium brevicornum, with a wide range of pharmacological and biological activities. In this paper, we investigated the effects of icariin on hyperlipidemia, and further evaluated whether icariin could improve unfavorable hemorheological parameters, attenuate platelet activation and facilitate the balance between plasmic plasminogen activator inhibitor-1 and tissue-type plasminogen activator activities in rabbits fed a high-cholesterol diet. Icariin reduced the levels of serum total cholesterol and low-density lipoprotein cholesterol, as well as the atherosclerotic burden. In addition, this compound has been found to improve the imbalance between plasmic plasminogen activator inhibitor-1 and tissue-type plasminogen activator activities, reduce platelet adhesiveness and aggregation and modulate unfavorable hemorheological variables in hypercholesterolemia. In conclusion, icariin has lipid-lowering effects and may be used in the treatment and prevention of thrombosis in the atherosclerotic process.
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