Journal
PLANTA MEDICA
Volume 79, Issue 18, Pages 1742-1748Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1351051
Keywords
Houttuynia cordata; Saururaceae; flavonoids; HSV-1; diasteriomeric epimers
Categories
Funding
- State Key Development Program of Basic Research of China [2009CB522300]
- Program for New Century Excellent Talents in University from the Ministry of Education of China [NCET-10-0120]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]
- Key Sci-tech Research Projects of Guangdong Province [8351063201000003]
Ask authors/readers for more resources
This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of the new compounds was obtained as a pair of inseparable diasteriomeric epimers due to the chiral carbon of hemiketal at C-3 ''. This phenomenon is rooted in the ring-chain tautomerism of the hemiketal functional group in solution, which was proved by dynamic NMR experiments. The new compounds 1-4 displayed inhibitory activities against herpes simplex virus 1, with respective IC50 values of 38.46, 14.10, 62.00 and 70.76 mu M, which was associated with the medicinal functions of H. cordata.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available