Journal
PLANTA MEDICA
Volume 78, Issue 13, Pages 1490-1514Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1298331
Keywords
herb-drug interaction; plant secondary metabolites; cytochrome P450 enzymes; transferases; ATP-binding cassette transporters; solute carrier membrane transport proteins; botanical dietary supplements; black cohosh; Echinacea; garlic; Ginkgo biloba; ginseng; goldenseal; kava; black pepper; piperine; Schisandra; milk thistle; St. John's wort; methylenedioxyphenyl containing compounds
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In Part 2 of this review, a critical examination of the pertinent scientific literature is undertaken in order to assess the interaction risk that popular dietary supplements may pose when taken concomitantlywith conventionalmedications. Botanicals most likely to produce clinically important herb-drug interactions are those whose phytochemicals act as mechanism-based inhibitors of cytochrome P450 enzyme activity (e.g., Hydrastis canadensis, Piper nigrum, Schisandra chinensis) or function as ligands for orphan nuclear receptors (e.g., Hypericum perforatum). In addition, several external factors unrelated to phytochemical pharmacology can augment the drug interaction potential of botanical supplements.
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