Journal
PLANTA MEDICA
Volume 78, Issue 4, Pages 383-U87Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1298143
Keywords
Harrisonia abyssinica; Simaroubaceae; harronin I; harrorin II; prenylated acetophenones; antimicrobial activity
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The ripe berries of Harrisonia abyssinica yielded two new prenylated acetophenones, namely 5-(ethan-1'''-one)-4,6-dihydroxy-7-(3'',3''-dimethylallyl)-2S-(1'S-hydroxy-1',5'-dimethylhex-4'-enyl)-2,3-dihydrobenzofuran (1) and 5-(2'''-hydroxyethan-1'''-one)-4,6-dihydroxy-7-(3'',3''-dimethylallyl)-2S-(1'S-hydroxy-1', 5'-dimethylhex-4'-enyl)-2,3-dihydrobenzofuran (2), herein named harronin I and harronin II, respectively. The compounds were isolated following activity guided fractionation and the structures were determined using 1D, 2D NMR spectroscopic, CD and MS spectrometric techniques. The methanol-dichloromethane mixture (1:1 v/v) crude extract exhibited strong antimicrobial activity against Candida albicans, Bacillus cereus, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, and Lactobacillus casei. Harronin I (1) showed a MIC of 5 mu g/mL against C. albicans, 6 mu g/mL against B. cereus, and more than 20 mu g/mL against other tested microorganisms. Harronin II (2) showed much weaker MIC values (> 100 mu g/mL) against all the tested microorganisms.
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