Journal
PLANTA MEDICA
Volume 78, Issue 5, Pages 472-479Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1298214
Keywords
lanostane triterpenoids; Schisandraceae; Schisandra glaucescens; FXR
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Funding
- NSFC [20802082, 30830115]
- Chinese Academy of Sciences [KSCX2-EW-Q-10, KSCX1-YW-R-24]
- Major State Basic Research Development Program of China [2009CB522303, 2009CB940900]
- Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
- Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
- State Key Laboratory of Phytochemistry and Plant Resources in West China
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Ten new triterpenoids, schiglausins A-J (1-10), as well as four known compounds, were isolated from the stems of Schisandra glaucescens. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.
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