Journal
PLANTA MEDICA
Volume 77, Issue 13, Pages 1542-1544Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1270782
Keywords
Zanthoxylum monophyllum; Rutaceae; lignans; alkaloids; antimicrobial; antimalarial activities
Categories
Funding
- NIH IMSD [GM55379]
- University of Mississippi
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From the leaves and bark of Zanthoxylum monophyllum, a new lignan, 3-methoxy-3',4'-methylenedioxylignan-4,8,9,9'-tetraol (1), has been isolated along with 22 known compounds (2-23), fifteen of them reported for the first time from Z. monophyllum. Their chemical structures were elucidated using detailed spectroscopic studies and chemical analysis. All compounds were evaluated for antimicrobial and antiprotozoal activities. Alkaloids bis-[6-(5,6-dihydro-chelerythrinyl)] ether (2) and 6-ethoxy-chelerythrine (4) exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 4-methoxy-N-methyl-2-quinolone (9) exhibited significant activity against MRSA (IC50 value of 8.0 mu M) while compound 5,8,4'-trihydroxy-3,7,3'-trimethoxyflavone (10) showed weak activity against Plasmodium falciparum.
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