Journal
PLANTA MEDICA
Volume 78, Issue 1, Pages 76-78Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1280251
Keywords
Phoma herbarum; Valsaceae; polyketide; marine fungus; neuraminidase inhibitor
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Funding
- NSFC [90813036, 30821006, 20802035, 21072092]
- MOST [2009ZX09501-013]
- JSNSF [BK2009010]
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Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.15 to 9.16 mu M.
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