Journal
PLANTA MEDICA
Volume 77, Issue 17, Pages 1924-1931Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1280020
Keywords
Pseudolarix kaempferi; Pinaceae; lignans; terpenoids; antimicrobial; cytotoxic
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Funding
- National Natural Science Foundation of China [30725048, 91013002, U1032602, 20972168]
- National Basic Research Program of China [2009CB522300]
- National New Drug Innovation Major Project of China [2011ZX09307-002-02]
- Chinese Academy of Sciences [KSCX2-YW-R-177]
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Seven new compounds, including four lignans, (+)-(8S, 8'S)-9,9'-dibenzoylsecoisolariciresinol (1), (+)-(8S*, 8'R*)-4,4'-dimethyloxomatairesinol (2), (+)-(7S*, 8R*, 8'R*, 9'S*)-9'-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8-32) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and cytotoxic activity against K562, HT29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines were assayed. Results indicated that the new compounds 3, 7, and some known compounds showed antimicrobial and cytotoxic activities.
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