Journal
PLANTA MEDICA
Volume 77, Issue 15, Pages 1735-1738Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1271040
Keywords
Trichosphaeriaceae; Nigrospora sp.; Kandelia candel (L.) Druce; metabolites; cytotoxicity; antimicrobial activity
Categories
Funding
- National Natural Science Foundation of China [20972197]
- Natural Science Foundation of Guangdong province of China [9151027501000055]
- Science & Technology Plan Project of Guangdong Province of China [2010B030600004]
- University-industry cooperation projects of Guangdong Province
- Ministry of Education [2008B090500171]
- Guangzhou Project of Science & Technology Planning [2010J1-E331]
- Fundamental Research Funds for the Central Universities [11lgjc01]
- Prize Fund for Excellent Middle Aged and Young Scientists of Shandong Province [BS2009HZ004]
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Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2S,5'R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybostrycin (6), were isolated from the marine endophytic fungus Nigrospora sp. (No. 1403) collected from the South China Sea. The structures were elucidated by spectroscopic methods, 1D, 2D NMR, and HREIMS. Compounds 5 and 6 showed moderate antitumor and moderate antimicrobial activity.
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