Journal
PLANTA MEDICA
Volume 76, Issue 16, Pages 1864-1866Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1249935
Keywords
Allium cepa; Alliaceae; zwiebelane A; polymyxin B; Saccharomyces cerevisiae
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Funding
- Japan Society for the Promotion of Science [20580083]
- Grants-in-Aid for Scientific Research [20580083] Funding Source: KAKEN
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Zwiebelane A (cis-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl sulfur compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.
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