Journal
PLANTA MEDICA
Volume 77, Issue 9, Pages 939-944Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250631
Keywords
Kopsia hainanensis; Apocynaceae; danuphyllin type; aspidofractinine type; chanofruticosinate type; antitussive activity
Categories
Funding
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2009ZX09301-001]
- Ministry of Science and Technology [2007DFC31030]
- Shanghai Commission of Science and Technology [08DZ1971401]
Ask authors/readers for more resources
Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the delta-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
