Journal
PLANTA MEDICA
Volume 77, Issue 1, Pages 66-69Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250122
Keywords
Pulsatilla koreana; Ranunculaceae; lignan; anticomplement activity
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Funding
- Korea Food and Drug Administration [09162KFDA540]
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Two new lignans, (2R,3R)-2 beta-(4 ''-hydroxy-3 ''-methoxybenzyl)-3 alpha-( 4'-hydroxy-3'-methoxybenzyl)-gamma-butyrolactone 2-O-(beta-D-glucopyranoside) (1) and (1S,2R,3S)-dimethyl-1,2,3,4-tetra-hydro-3,6,7-trihydroxy-1-(3', 4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC50 value of 75.9 mu M, compounds 8 and 9 had moderate effects with IC50 values of 182.2 and 166.5 mu M, respectively.
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