Journal
PLANTA MEDICA
Volume 76, Issue 11, Pages 1080-1086Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1250162
Keywords
cell-based assays; protein kinases; cytotoxicity; natural products
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Natural products have been the biggest single source of anticancer drugs and there are continued efforts to explore the chemical diversity provided by nature in order to find new lead compounds. Bioassay test methods have developed into high throughput screening assays using both cell-based and molecular approaches. The various ways to detect effects on cell viability and cell proliferation are summarised and examples are given of developments using three-dimensional cultures and cancer stem cells. Cell-based reporter assays have also been created in order to look more directly for effects on specific physiological pathways. The molecular assays include those directed at microtubules and related proteins and at many different protein kinases.
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