Journal
PLANTA MEDICA
Volume 75, Issue 15, Pages 1591-1596Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1185868
Keywords
Dracocephalum forrestii; Lamiaceae; phenylethanoids; lignans; RAW 264.7 macrophages; NO
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Funding
- Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- NCET Foundation
- NSFC [30725045]
- National 863 Program [2006AA02Z338]
- Shanghai Leading Academic Discipline Project [13906]
- Ministry of Science and Technology of China [2004DKA30430, 2005DKA21 006]
- Ministry of Education of China [B08044, CUN 985-3-3]
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A systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8-O-[(6-O-syringoyl)-beta-D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol beta-D-glucopyranoside (2), 4-O-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9 ''-O-n-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.
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