The Bioactive Metabolites of the Mangrove Endophytic Fungus Talaromyces sp ZH-154 Isolated from Kandelia candel (L.) Druce

Bioactivity-directed fractionation of the extract of the mangrove endophytic fungus Talaromyces sp. ZH-154, which was isolated from the stem bark of Kandelia candel (L.) Druce, Rhizophoraceae, afforded two new metabolites, 7-epiaustdiol (1) and 8-O-methylepiaustdiol (2), together with the known compounds, stemphyperylenol (3), skyrin (4), secalonic acid A (5), emodin (6), and norlichexanthone (7). Their structures were elucidated on the basis of spectroscopic evidences including CD, MS, and 1D, 2D NMR techniques. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction. All isolated compounds were evaluated for their antimicrobial and in vitro cytotoxic activities.