Journal
PLANTA MEDICA
Volume 76, Issue 3, Pages 291-294Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1186063
Keywords
Dioscorea septemloba; Dioscoreaceae; antitumor; cholestane glycoside; trihydroxy fatty acid
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Funding
- Chinese Academy of Sciences [KGCX2-SW-213]
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Two new steroidal glycosides, named dioseptemlosides I (1) and J (2), along with two known trihydroxy fatty acids, (12Z,15Z)-9,10,11-trihydroxy-12,15-octadecadienoic acid (3) and (12Z)-9,10,11-trihydroxy-12-octadecenoic acid (4), were isolated from the rhizomes of Dioscorea septemloba. Their structures were determined by HRESIMS, 1D and 2D NMR experiments, physical data, and chemical methods. The antitumor activity of compounds 1-4 was evaluated against three tumor cell lines and all of them were inactive at a concentration of 10 mu M.
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