Investigation of Two Flacourtiaceae Plants: Bennettiodendron leprosipes and Flacourtia ramontchi

Investigations of two Flacourtiaceae plants, Bennettiodendron leprosipes and Flacourtia ramontchi, resulted in the isolation and structural elucidation of six new constituents including two phenolic glycosides (1 and 2), one lignan (3), two lignan glycosides (4 and 5), and a monoterpene glycoside (6), together with 22 known compounds (7-28). The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The selected isolates 1, 2, 8-10, 22-26, and some phenolic glycosides 29-42 previously isolated from another Flacourtiaceae plant, Itoa orientalis, were tested against snake venom phosphodiesterase I (PIDE I) activity. The result indicated that 22, 30, 32, 34, and 40 exhibited moderate inhibitory activities against PDE I with the values ranging from 13.15 to 20.86%, and 1, 8,10, 25, 31, 33, 35, 38, 39, and 41 showed weak inhibitory activity.