Journal
PLANTA MEDICA
Volume 75, Issue 11, Pages 1241-1245Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1185506
Keywords
Myristica fragrans; Myristicaceae; cytotoxicity; antioxidative activity; phenylpropanoids
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Funding
- National Natural Science Foundation of China [30470196, 30472136]
- Chinese National Programs for High Technology Research and Development [2007AA09Z447]
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Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (-)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3'-methoxy-8- methyl-1'-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Delta 8'-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7'R,8'S)-4,5'-diliydroxy-3,3'-dimethoxy-7,7'-epoxylignan (4) showed the corresponding activities with IC50 values of 39.4 and 2.11 mu M, respectively.
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