Journal
PLANTA MEDICA
Volume 75, Issue 8, Pages 843-847Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1185376
Keywords
Epimedium brevicornum; Berberidaceae; prenylflavonol; anti-inflammatory; biogenetic relationship
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Funding
- National Excellent Doctoral Dissertation of P.R. China [200780]
- National Natural Science Foundation of China [20862011]
- Program for New Century Excellent Talents in University [NCET-06-0824]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2005py01-32]
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In an attempt to search for bioactive natural products, two new prenylflavonols, 2-hydroxy-3-en-anhydroicaritin (1) and 2-hydroxy-beta-anhydroicaritin (2), were isolated from the Chinese medicinal herb Epimedium brevicornum. Their structures were determined by 1D and 2D NMR spectroscopic analysis. The effects of compounds 1 and 2 on cytokine production ill vitro were investigated. Compound I could significantly downregulate tumor necrosis factor-alpha (TNF-alpha) production and increase interleukin-10 (IL-10) production. These results suggested that compound 1 may have anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated mouse macrophages. In addition, the biogenetic relationships among compounds 1 and 2 are discussed.
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