Journal
PLANTA MEDICA
Volume 75, Issue 5, Pages 528-533Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1185332
Keywords
marine cyanobacteria; Lyngbya confervoides; cyclodepsipeptides; elastase
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Funding
- U.S Department of Commerce [NA060AR4170014]
- NIGMS [P41 GM08621 0]
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Three unusual tiglic acid-containing cyclodepsipeptides, possessing the revised regioisomeric structures for largamides A - C (1-3), have been isolated from the marine cyanobacterium Lyngbya confervoides collected from southeastern Florida. The two-dimensional structures were determined by NMR spectroscopy and the absolute configurations by chiral HPLC analysis of degradation products. Compounds 1-3 are moderate inhibitors of mammalian elastase activity in vitro with IC50 values ranging from 0.53 to 1.41 mu M.
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