Journal
PLANTA MEDICA
Volume 76, Issue 7, Pages 708-712Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1240627
Keywords
Garcinia afzelii; Guttiferae; benzopyrones; xanthones; antiviral studies; cytotoxicity
Categories
Funding
- AUF
- TWAS [05-148 RG/CHE/AF/AC]
- Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO) [G.0188.07]
- International Consortium for Antivirals (ICAV)
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The new compounds guttiferone O (1) and 3-methoxycheffouxanthone (2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (3), smeathxanthone A (4), 1,5-dihydroxyxanthone (5), 1,6-dihydroxy-5-methoxyxanthone (6), cheffouxanthone (7), 1,3,5-trihydroxyxanthone (8), smeathxanthone B (9), isoxanthochymol (10) and guttiferone E (11). Their structures were elucidated by means of 1D and 2D-NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.
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