Journal
PLANTA MEDICA
Volume 75, Issue 3, Pages 216-221Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088378
Keywords
EGCG; Caenorhabditis elegans (Rhabditidae); lifespan; free radicals; juglone; Comellia sinensis (Theaceae)
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Funding
- Nikon Imaging Centre of Heidelberg University
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Epigallocatechin gallate (EGCG) is a major green tea polyphenol with pronounced antioxidative activity. The effects of EGCG on lifespan and stress resistance in wild-type N2 and transgenic strains of Caenorhabditis elegans [hsp-16.2/GFP, mev-1(kn1), fem-1 (hc17)] were investigated. The expression of hsp-16.2 (induced by the pro-oxidant juglone) and the intracellular levels of H2O2 were inhibited by EGCG treatment. Daily administration of 220 mu M EGCG increased the mean lifespan by 10.14% and 14.27% in N2 and fem-1(hc17) strains, respectively, and 55 mu M EGCG increased the mean lifespan in mev-1(kn1) by 16.11%. The survival rate was also increased under lethal oxidative stress by 65.05%. These findings suggest that the increased mean lifespan and stress resistance in C. elegans apparently depend, among other factors, on the antioxidant properties of EGCG.
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