Antifungal Triterpene Glycosides from the Sea Cucumber Bohadschia marmorata

Four new holostan-type triterpene glycosides, marmoratoside A (1), 17 alpha-hydroxy impatienside A (2), marmoratoside B (3), 25-acetoxy bivittoside D (4), together with two known triterpene glycosides, impatienside A (5) and bivittoside D (6), were isolated from the sea cucumber Bohadschia marmorata Jaeger. On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structures of the new triterpene glycosides were elucidated. Compounds 1, 2, 5, and 6 exhibited significant antifungal activity against six strains (0.70 <= MIC80 <= 2.81 mu M).