Journal
PLANTA MEDICA
Volume 74, Issue 12, Pages 1463-1467Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1081331
Keywords
Pterocaulon alopecuroides; Asteraceae; Flavonoids; antibacterial activity
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Funding
- Consejo de Investigacion de la Universidad Nacional de Salta
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Three flavonoids, (2R,3R)-5,4'-dihydroxy-3'-O-methyl-7-(gamma,gamma-dimethylallyloxy)dihydroflavonol 1, (2R,3R)-5,7,4'-trihydroxy-3'-O-methyl-6-(alpha,alpha-dimethylallyl)dihydroflavonol 2, and (2R,3R)-5,7,4'-trihydroxy-6-(alpha,alpha-dimethylallyl)dihydroflavonol 3, together with three known flavonoids (4-6), were isolated from the aerial parts of Pterocaulon alopecuroides. The structures of the compounds were determined by mass and by 1 D and 2 D NMR spectroscopy. Screening of the antibacterial activity of all six compounds was conducted by a disc diffusion test against Bacillus cereus, Bacillus subtilis, Salmonella typhimurium and Proteus mirabilis. The minimum inhibitory concentration (MIC) of the active compounds (2, 3, 4, 6) was determined by a microdilution assay. These compounds were active only against both Gram (+) bacteria with MIC values <= 200 mu g/mL.
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