Journal
PLANTA MEDICA
Volume 74, Issue 12, Pages 1457-1462Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1081336
Keywords
Myristica crassa; Myristicaceae; Malabaricone; Acylphenol; Acetylcholinesterase; LC-MS
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Funding
- Institut de Chimie des Substances Naturelles (ICSN-CNRS)
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A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa. Three new dimeric acylphenols, giganteone C (5), maingayones B and C (6 and 7) were isolated together with the known malabaricones B and C (2 and 3) and giganteone A (4). Compounds 2 and 3 possess significant inhibitory activity on acetylcholinesterase. LC/MS study was particularly useful to discriminate structures of compounds 6 and 7.
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