Journal
PLANTA MEDICA
Volume 74, Issue 3, Pages 267-272Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1034311
Keywords
connabis sativo; Cannalbaceae; epoxy cannabigerolic acid; cannabispirone; antimicrobial activity; antileishmanial activity
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Funding
- NCRR NIH HHS [1P20 RR 021929-01, P20 RR021929] Funding Source: Medline
- NIDA NIH HHS [N01 DA 57746] Funding Source: Medline
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Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, ()-6,7-trans-epoxycannabigerolic acid (2), (+/-)-6,7-cis-epoxycannabigerolic acid (3), (+/-)-6,7-cis-epoxycannabigerol (4), (+/-)-6,7-trans-epoxycannabigerol (5), 5 -methyi-4-pentylbiphenyl-2,2',6-trioI (7), and 7-methoxycannabispirone (8), along with seven known compounds namely, cannabigerolic acid (1), 5 -methoxycannabigerolic acid (6), cannabispirone (9), beta-cannabispiranol (10), dehydrocan-nabifuran (11), cannflavin B (12) and cannabigerol (13). The anti microbial as well as the antileishmanial activities were investigated.
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