Journal
PLANTA MEDICA
Volume 75, Issue 1, Pages 76-79Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088344
Keywords
Litsea cubeba; Lauraceae; isoquinoline alkaloids; antimicrobial activity; (+)-N-(methoxycarbony)-N-norboldine; (+)-isoboldine beta-N-oxide
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Funding
- National Natural Science Foundation of China [C30670214]
- National Basic Research Program of China (973 Program) [2009CB522300]
- Chinese Academy of Science [KSCX2-YW-N-014]
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Bioassay-guided fractionation of the alkaloidal extract of the aerial part of Litsea cubeba led to the isolation of two new isoquinoline alkaloids, (+)-N-(methoxycarbonyl)-N-norboldine (1) and (+)-isoboldine beta-N-oxide (2), together with 11 known analogues (3-13). Their structures were established by extensive spectroscopic techniques and by comparing spectroscopic data with those in the literature. Compounds 1 and 4 showed antimicrobial activities. This is the first report on the presence of compounds 1, 2, 6, 8, 9, 11, and 12 in this plant and on the antimicrobial activities of 1 and 4. The bioactivities of isoquinoline alkaloids are also at least partly responsible for the pharmacological function of the folk medicinal plant Litsea cubeba.
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