Journal
PLANTA MEDICA
Volume 74, Issue 4, Pages 413-416Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1034347
Keywords
Mallotus philippensis; Euphorbiaceae; stem bark; 3 alpha-hydroxy-D : A-friedooleanan-2-one; Epstein-Barr virus early antigen; two-stage mouse skin carcinogenesis; DIMBA; TPA
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Four known friedelane-type triterpenoids, friedelin (1), 3-hydroxy-D:A-friedoolean-3-en-2-one (2), 20-hydroxy-D:A-friedooleanan-3-one (3), and 3 alpha-hydroxy-D:A-friedooleanan-2-one (4), and two known lupane-type triterpenoids, lupeol (5) and betulin (6), were isolated from the stem bark of Mallotus philippensis. Isolates 1-4 and their synthetic analogues, 3-acetoxy-D:A-friedoolean-3-en-2-one (2a) and 3 alpha-acetoxy-D:A-friedooleanan-2-one (4a), were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA). The inhibitory effect of compounds 2 (IC50 = 292 mol ratio/32 pmol/TPA) and 4 (IC50=288) was stronger than those of the other compounds tested and the positive control, curcumin (IC50=343). Compound 4 strongly inhibited mouse skin tumor promotion in an in vivo two-stage carcinogenesis model. Studies have been conducted to identify the biologically active compounds extracted from the leaves, bark, and cones of trees that currently have no specific commercial use and are therefore treated as waste in the forestry industry.
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