Journal
PLANTA MEDICA
Volume 74, Issue 15, Pages 1769-1773Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088322
Keywords
Passiflora incarnata; Passifloraceae; anxiolytic effect; benzodiazepines; elevated plus maze/open field; GABA receptor; 5-HT1A receptor
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The purpose of this research was to assess the anxiolytic properties of a phytochemically characterized commercial extract from Passiflora incarnata (PI; Passifloraceae) in the elevated Plus maze test in mice. Using an HPLC method, the flavonoids homoorientin, orientin, vitexin, and isovitexin were identified as major compounds. Following oral administration, the extract exerted an anxiolytic effect that was comparable to diazepam (1.5 mg/kg) at a dose of 375 mg/kg and exhibited a U-shaped dose-response curve. In addition, antagonism Studies using the GABA(A)/benzodiazepine receptor antagonist flumazenil and the 5-HT1A-receptor antagonist WAY-100635 Were conducted. The active dose was effectively antagonized by flumazenil, but not by WAY-100635. This Study is the first demonstration of the in vivo, GABA-mediated anxiolytic activity of an HPLC- characterized extract of Passiflora incarnata.
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