Journal
PLANT FOODS FOR HUMAN NUTRITION
Volume 66, Issue 1, Pages 78-84Publisher
SPRINGER
DOI: 10.1007/s11130-011-0214-8
Keywords
Alkaloids; Antioxidant; Antiproliferative; Oxidative stress; Phenolic compounds; ROS; Theophylline
Funding
- CICYT [CTQ2006-03794/BQU]
- Instituto de Salud Carlos III [CB06_01_0074, PI060624]
- Generalitat de Catalunya [2005SGR 00662]
- Institute for Research in Biomedicine
- Barcelona Science Park
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BPD/20736/2004]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/20736/2004] Funding Source: FCT
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This work aimed to evaluate the phytochemical content and to determine the antioxidant and cytotoxic activities of methanol extracts of the carob tree (Ceratonia siliqua L.) germ flour. The extracts were rich in phenolic compounds, had considerable antioxidant activity, and reduced the viability of cervical (HeLa) cancer cells. The chemical content and the biological activities of the extracts were significantly affected by gender and cultivar. Female cultivar Galhosa had the highest levels of phenolic compounds, and the highest antioxidant activity. Extracts from the hermaphrodite trees and from the female cultivars Galhosa and Costela/Canela exhibited the highest cytotoxic activity. The most abundant compound was theophylline. The phenolic content was correlated to both antioxidant and cytotoxic activities. Our findings provide new knowledge about the health implications of consuming food supplemented with carob germ flour.
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