Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 35, Issue 5, Pages 1050-1055Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.114.304649
Keywords
atherosclerosis; chemokines; monocytes
Categories
Funding
- DFG [SO876/3-1, SO876/6-1, SFB914 TP B8, SFB1123 TP A6, SFB1123 TP B5]
- Else Kroner Fresenius Stiftung
- NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- VIDI) [91712303]
- LMUexcellence initiative
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Atherosclerosis is a chronic inflammatory disease of large arteries and, among others, characterized by continuous influx of monocytes into the subendothelial space, subsequent macrophage accumulation, and foam cell formation. Chemokines and their receptors tightly orchestrate monocyte trafficking and fate from birth to death. This brief review summarizes our current understanding of the interplay between monocytes and chemokines entertaining crucial processes in atherosclerosis development, progression, and regression.
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