Journal
PLANT CELL AND ENVIRONMENT
Volume 34, Issue 5, Pages 811-820Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-3040.2011.02284.x
Keywords
26S proteasome; Anatase TiO2 nanoparticles; Arabidopsis thaliana; microtubules; nanotoxicity biomarker; tubulin
Categories
Funding
- University of Kentucky
- Kentucky Science and Engineering Foundation [148-502-06-189]
Ask authors/readers for more resources
In spite of the mounting concerns, current understanding of the extent and mechanisms of phytotoxicity of manufactured nanomaterials remains limited. Here we show that in Arabidopsis thaliana, ultra-small anatase TiO2 nanoparticles cause reorganization and elimination of microtubules followed by the accelerated and 26S proteasome-dependent degradation of tubulin monomers. Similar to other microtubule-disrupting agents, TiO2 nanoparticles induce isotropic growth of root cells. Because microtubules are essential for the normal function of all eukaryotic cells, these results reveal a potentially important consequence of environmental pollution by this widely used nanomaterial.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available