Journal
PLANT CELL
Volume 24, Issue 10, Pages 3892-3906Publisher
AMER SOC PLANT BIOLOGISTS
DOI: 10.1105/tpc.112.101550
Keywords
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Engineering and Physical Sciences Research Council
- BBSRC responsive mode grant
- BBSRC Professorial Research Fellowship
- Royal Society and Wolfson Foundation
- BBSRC [BB/G023972/1, BB/D019613/1, BB/H020314/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H020314/1, BB/D019613/1, BB/J009717/1, BB/G023972/1] Funding Source: researchfish
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Over recent decades, we have gained detailed knowledge of many processes involved in root growth and development. However, with this knowledge come increasing complexity and an increasing need for mechanistic modeling to understand how those individual processes interact. One major challenge is in relating genotypes to phenotypes, requiring us to move beyond the network and cellular scales, to use multiscale modeling to predict emergent dynamics at the tissue and organ levels. In this review, we highlight recent developments in multiscale modeling, illustrating how these are generating new mechanistic insights into the regulation of root growth and development. We consider how these models are motivating new biological data analysis and explore directions for future research. This modeling progress will be crucial as we move from a qualitative to an increasingly quantitative understanding of root biology, generating predictive tools that accelerate the development of improved crop varieties.
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