Journal
PLANT CELL
Volume 22, Issue 6, Pages 1777-1791Publisher
AMER SOC PLANT BIOLOGISTS
DOI: 10.1105/tpc.109.069575
Keywords
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Funding
- Crop Functional Genomics Center of the 21st Century Frontier Research Program [CG3313]
- Rural Development Administration [20070401034001]
- Ministry of Education, Science, and Technology, Korea
- Korean Government (Ministry of Education and Human Resource Development) [F00026]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19380069]
- Rural Development Administration (RDA), Republic of Korea [20070401034001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Temporal and spatial variation in the levels of and sensitivity to hormones are essential for the development of higher organisms. Traditionally, end-product feedback regulation has been considered as the key mechanism for the achievement of cellular homeostasis. Brassinosteroids (BRs) are plant steroid hormones that are perceived by the cell surface receptor kinase Brassinosteroid Insensitive1. Binding of these hormones to the receptor activates BR signaling and eventually suppresses BR synthesis. This report shows that RAVL1 regulates the expression of the BR receptor. Furthermore, RAVL1 is also required for the expression of the BR biosynthetic genes D2, D11, and BRD1 that are subject to BR negative feedback. Activation by RAVL1 was coordinated via E-box cis-elements in the promoters of the receptor and biosynthetic genes. Also, RAVL1 is necessary for the response of these genes to changes in cellular BR homeostasis. Genetic evidence is presented to strengthen the observation that the primary action of RAVL1 mediates the expression of genes involved in BR signaling and biosynthesis. This study thus describes a regulatory circuit modulating the homeostasis of BR in which RAVL1 ensures the basal activity of both the signaling and the biosynthetic pathways.
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