Journal
PLACENTA
Volume 34, Issue 11, Pages 1105-1109Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2013.08.003
Keywords
Transport; Endocytosis; Yolk sac; Megalin; Cubilin
Ask authors/readers for more resources
Megalin and cubilin are multifunctional endocytic receptors associated with many transporting epithelia. They play an essential role in transport of nutrients through the visceral yolk sac of rodents during embryogenesis. Here, we immunolocalise them to the endodermal layer of the human yolk sac, and to the syncytiotrophoblast and cytotrophoblast cells of placental villi. In villi, the protein level of both receptors increased with gestation. The mRNA for megalin remained constant, while that encoding cubilin increased with gestation. These results suggest megalin and cubilin may be important in human maternal-fetal transfer, and that they increase across gestation to facilitate this function. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available