Journal
PLACENTA
Volume 34, Issue 1, Pages 62-66Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2012.10.015
Keywords
Umbilical cord diameter; Percentile curve; Nomogram; Birth weight; Placenta; Pathology
Funding
- Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, CANADA
- Department of Obstetrics and Gynecology (Division of Maternal-Fetal Medicine), Mount Sinai Hospital, Toronto, CANADA
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Objective: The aims of this study were to develop a nomogram of umbilical cord diameter (UCD) for pathologic examination of the placenta, to identify the umbilical cord components responsible for variations in UCD, and to examine the relationship between UCD and other placental pathologic features and perinatal outcome. Study design: We prospectively collected 497 umbilical cords between 18 and 41 weeks' gestation over a 1-year period. Fresh-tissue UCD were grouped according to gestational age and compared to sonographic and histological measurements. Associations between UCD percentile and placental pathologic findings or obstetrical outcomes were examined. Results: Mean UCD increased with gestational age until a plateau at 1.0 cm in the third trimester, a value that was 0.56 cm less than sonographic measurements prior to delivery and 0.17 cm greater than UCD measured histologically. Umbilical cord components varied with UCD percentile, with umbilical vessel area increased in thick cords (p < 0.001) and Wharton's jelly area reduced in thin cords (p = 0.002). Thin umbilical cords were associated with at least one pathologic histological placental finding (p = 0.02), low placental weight (p < 0.001), single umbilical artery (p = 0.02), marginal cord insertion (p = 0.01), and low infant birth weight (p < 0.001). Conclusions: This study provides reference curves for post-delivery UCD from 18 to 41 weeks' gestation for use by perinatal pathologists. We show that increased UCD is a function of increased umbilical blood vessel volume and decreased UCD is a function of decreased Wharton's jelly volume. UCD shows a strong association with placental and infant birth weight. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
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