Journal
PLACENTA
Volume 34, Issue 12, Pages 1190-1195Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2013.09.013
Keywords
Preeclampsia; Microarray; Expression profiles; Connectivity Map database
Funding
- National Nature Science Foundation of China [81100446]
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Preeclampsia (PE), which affects 2-7% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. To better understand the pathophysiology of PE, the gene expression profiles of placental tissue from 5 controls and 5 PE patients were assessed using microarray. A total of 224 transcripts were significantly differentially expressed (>2-fold change and q value < 0.05, SAM software). Gene Ontology (GO) enrichment analysis indicated that genes involved in hypoxia and oxidative and reductive processes were significantly changed. Three differentially expressed genes (DEGs) involved in these biological processes were further verified by quantitative real-time PCR. Finally, the potential therapeutic agents for PE were explored via the Connectivity Map database. In conclusion, the data obtained in this study might provide clues to better understand the pathophysiology of PE and to identify potential therapeutic agents for PE patients. (C) 2013 Elsevier Ltd. All rights reserved.
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