Journal
PLACENTA
Volume 33, Issue 8, Pages 652-654Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2012.05.003
Keywords
Twin-twin transfusion syndrome; Monochorionic placenta; Arterio-arterial anastomosis; Twin anemia-polycythemia sequence
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We performed a matched case-control study to analyze the placental angioarchitecture, in particular the diameter of arterio-arterial (AA) anastomoses in monochorionic placentas from pregnancies with twin-twin transfusion syndrome (TITS) compared to a control group of uncomplicated monochorionic placentas. Placental angioarchitecture was analyzed using colored dye injection. AA anastomoses were detected in 37% (14/38) of TTTS placentas versus 91% (209/228) in control placentas (p < 0.001). The median diameter of AA anastomoses in the group with and without TTTS was 1.9 mm and 2 mm, respectively (p = 0.711). In conclusion, our findings show that AA anastomosis occur less frequently in TITS placentas, supporting the concept of the protective role of AA anastomoses in TTTS. However, the size of the AA anastomosis, when present, does not appear to influence the pathophysiology of the disease. (C) 2012 Elsevier Ltd. All rights reserved.
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