Journal
PLACENTA
Volume 32, Issue -, Pages S182-S185Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2011.01.009
Keywords
Uterine natural killer cells; Human chorionic gonadotropin; Preeclampsia; T regulatory cells; Angiogenesis
Funding
- NCRR NIH HHS [P20 RR018728, P20RR018728, P20 RR018728-07] Funding Source: Medline
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Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown. Marked by insufficient trophoblast invasion and poor spiral artery remodeling, preeclampsia has also been linked to immune dysregulation. Here we discuss the roles of hCG in the context of endovascular cross-talk between trophoblasts and endothelial cells and immune tolerance. We propose that functional and glycosylation modifications of hCG may contribute to the pathogenesis of preeclampsia. (C) 2011 Published by IFPA and Elsevier Ltd.
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