Journal
PLACENTA
Volume 31, Issue 11, Pages 1019-1022Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2010.09.008
Keywords
Abortion; Decidua; DC-SIGN; Dendritic cells; Pregnancy
Funding
- Ministerio de Educacion y Ciencia [SAF2006-05689]
- Fondo de Investigacion Sanitaria del Ministerio de Sanidad of Spain [PS09/00339]
- Servicio Andaluz de Salud (SAS) of the Regional Government of Andalucia [PFI 3/02, TCMR 0010/2006]
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Recent studies showed that some functions of decidual dendritic cells appear to be essential for pregnancy. In humans, decidual dendritic cells are identifiable by their expression of DC-SIGN. We compared the subpopulations of human decidual DC-SIGN+ cells from first-trimester normal pregnancies and spontaneous abortions by flow cytometry. In normal decidua, DC-SIGN+ cells expressed antigens associated with immature myeloid dendritic cells. In samples from spontaneous abortions, we detected decidual DC-SIGN+ cells with an antigen phenotype equivalent to that of DC-SIGN+ cells from normal pregnancies, but at a significantly lower proportion (P < 0.01). Our results support the hypothesis that dendritic cells play a role in normal or pathological human pregnancy outcomes. (C) 2010 Elsevier Ltd. All rights reserved.
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