Journal
PLACENTA
Volume 29, Issue 5, Pages 436-438Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2008.02.010
Keywords
angiogenesis; genes; placenta; pregnancy; umbilical cord; pre-eclampsia
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Gene expression studies have demonstrated the altered expression level of placental angiogenesis related genes in severe pre-eclampsia (PE). In cord compression, the transportation of oxygen from the placenta to the fetus is blocked, and it is speculated that during blockade the originally hypoxic placenta may become hyperoxic. We compared the placental gene expression profiles of one pre-eclamptic patient with cord compression (the index patient) to the profiles of patients with PE and those of normal pregnancy controls (including one woman with cord compression). The gene expression of the cord compression PE patient resembled that observed in the normal pregnancies. We hypothesize that umbilical blockade may in a short period of time lead to placental hyperoxia, which in turn has an effect on angiogenic gene expression profile. (C) 2008 Elsevier Ltd. All rights reserved.
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