Journal
PITUITARY
Volume 15, Issue 2, Pages 202-208Publisher
SPRINGER
DOI: 10.1007/s11102-011-0307-2
Keywords
Hypophysitis; Necrosis; Pituitary infarction
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Funding
- Heidenreich-von-Siebold grant (Georg-August-University Gottingen)
- NIH [DK 080351]
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We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulo-hypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.
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