Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 26, Issue 5, Pages 634-645Publisher
WILEY
DOI: 10.1111/pcmr.12134
Keywords
melanocytes; Schwann cells; NF1; Carney complex; desmoplastic melanoma
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Melanocytes are pigment-producing cells that reside in the skin, eyes, ears, heart, and central nervous system meninges of mammals. Schwann cells are glial cells, which closely associate with peripheral nerves, myelinating, and sheathing them. Melanocytes and Schwann cells both arise from the neural crest during development, and some melanocytes arise directly from Schwann cell precursors lining developing spinal nerves. In this review, we explore the connections between melanocytes and Schwann cells in development and transformation.
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