Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 26, Issue 1, Pages 39-57Publisher
WILEY
DOI: 10.1111/pcmr.12041
Keywords
molecular targets; melanoma; invasion; metastasis; anticancer therapy; plasticity
Categories
Funding
- Cancer Research UK [C33043/A12065]
- Royal Society [RG110591]
- Cancer Research UK [12065] Funding Source: researchfish
Ask authors/readers for more resources
Metastatic cutaneous melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive melanoma cells need to change their cytoskeletal organization and alter contacts with the extracellular matrix and the surrounding stromal cells. Melanoma cells can use different migratory strategies depending on varying environments to exit the primary tumour mass and invade surrounding and later distant tissues. In this review, we have focused on tumour cell plasticity or the interconvertibility that melanoma cells have as one of the factors that contribute to melanoma metastasis. This has been an area of very intense research in the last 5 yr yielding a vast number of findings. We have therefore reviewed all the possible clinical opportunities that this new knowledge offers to both stratify and treat cutaneous malignant melanoma patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available